A punch biopsy is a type of skin biopsy. It is a diagnostic procedure that punches a hole in the skin to acquire tissue for laboratory examination, usually through microscopy or tissue culture. Skin biopsies, compared with biopsies of other organs, are relatively low-risk procedures that are conducted under local anesthesia, with very few associated complications. Punch biopsy is one of the three main types of skin biopsies. The other two are shave and excisional biopsies.

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